Related Experiment Video
Updated: Apr 25, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
Effects of dexmedetomidine on outcomes following craniocerebral operation - a meta-analysis
Wang Wenjie1, Lu Houqing1, Sun Gengyun2
1Department of ICU, Tongling Clinical College of Anhui Medical University, Tongling 244000, Anhui Province, China(1).
Objective:
To evaluate the effect of dexmedetomidine on outcomes following craniocerebral operation and provide evidence for individualized medication.
Methods:
We searched the Cochrane Library, PubMed, Springer, CNKI, Wanfang Data Resource and other Chinese and foreign databases with electronic retrieval, within the period 1990-2013, for records relating to dexmedetomidine, brain pharmacokinetics and clinical randomized controlled studies. Records were assessed using the Cochrane system evaluation method for assessing the quality of research, using Revman 5.1 Meta-analysis software.
Results:
After screening and removal of duplicate documents there were 22 English and 44 Chinese articles, among which there were eight describing clinical trials, with a total of 412 cases. Meta-analysis showed that dexmedetomidine on rate during craniocerebral operation (standardized mean difference=-8.32, 95% confidence interval [CI] -10.38 to 6.26, P<0.00001), and blood pressure (standardized mean difference=-3.37, 95% CI -5.36 to 1.38, P<0.00001). The study had good heterogeneity using random effects model analysis, and there was no publication bias.
Conclusion:
Dexmedetomidine can reduce the hemodynamic response and play a role in brain protection.
Related Concept Videos
Parenteral Anesthetics: Overview
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Depolarizing Blockers: Pharmocokinetics
Stages of General Anesthesia
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Skeletal Muscle Relaxants: Therapeutic Uses

