Acute sporadic hepatitis non A non B clinical features and biochemical profile

Hepatitis Non A Non B is the commonest type of sporadic hepatitis in Pakistan. To document its clinicopathological pattern, one hundred consecutive cases were studied. The clinical presentation indicates that it is a disease of mild severity presenting with anorexia and dark coloured urine. The rise in serum bilirubin transaminases and alkaline phosphatase is moderate. Monophasic pattern of transaminase elevation is seen. Chronic sequelae do not occur. The disease shows certain differences from western countries and Japan. It resembles hepatitis A. The possibility that it is caused by a closely related virus may have to be considered.