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Published on: April 11, 2016
Nanotheranostics in evidence based personalized medicine
1Saint James School of Medicine, Plaza Juliana 4, Kralendijk, Bonaire, Dutch Caribbean, The Netherlands. Sharma@mail.sjsm.org.
Nanotheranostic strategies offer safe, economical, and effective treatments for cancer, cardiovascular, and neurodegenerative diseases. These advances in nanotechnology facilitate evidence-based personalized medicine (EBPM) for improved patient outcomes.
Area of Science:
- Nanotechnology and Nanomedicine
- Pharmacology and Therapeutics
- Biomarker Discovery
Background:
- Efficient drug delivery is crucial for novel drug discovery and personalized medicine.
- Nanotechnology provides cellular, molecular, and genetic insights for tailored treatments.
- Pegylated liposomes and nanocarriers improve drug pharmacodynamics for various diseases.
Purpose of the Study:
- To review recent advances in nanotheranostic strategies for evidence-based personalized medicine (EBPM).
- To highlight the role of nanotechnology in treating cancer, cardiovascular diseases, and neurodegenerative disorders.
- To discuss novel biomarkers and their therapeutic implications.
Main Methods:
- Review of current literature on nanotheranostics and drug delivery systems.
- Analysis of nanotechnology applications in cancer chemotherapeutics, including liposomes and block copolymers.
- Exploration of emerging biomarkers like microRNA, metallothioneins, and Charnoly bodies (CBs).
Main Results:
- Liposomal drug encapsulation enhances treatment for cancer, cardiovascular, and neurodegenerative diseases.
- Targeted delivery of siRNA and oligonucleotides shows promise against multi-drug resistant (MDR) cancers.
- Novel biomarkers (microRNA, MTs, α-synuclein, CBs) offer new therapeutic avenues.
Conclusions:
- Nanotheranostic strategies are key to achieving safe, economical, and effective EBPM.
- Targeted nanoparticles (NPs) loaded with CB antagonists or agonists hold potential for treating complex diseases.
- Selective CB modulation may offer targeted cancer therapy with reduced side effects.
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