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Updated: Apr 25, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
[Inflammasome and its role in immunological and inflammatory response at early stage of burns]
Fang Zhang1, Jiahui Li1, Zhaofan Xia1
1Institute of Burns, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China.
Abstract:
Inflammasomes are large multi-protein complexes that serve as a platform for caspase-1 activation, and this process induces subsequent maturation and secretion of the proinflammatory cytokines IL-1β and IL-18, as well as pyroptosis. As an important component of the innate immune system, early activation of inflammasomes in a variety of immune cell subsets can mediate inflammatory response and immunological conditions after burn injury. Here, we review the current knowledge of inflammasomes and its role in immunological and inflammatory response at the early stage of burn injury.
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