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[Role of dysfunction of macrophage in intractable diabetic wound]

Shengyong Cui1, Yan Liu1, Xiong Zhang1

  • 1Department of Burns and Plastic Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.

Zhonghua Shao Shang Za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns
|September 2, 2014
PubMed

Insights

Diabetic wound healing is impaired by altered macrophage function. Exogenous growth factors may improve healing by regulating macrophage phenotypes in these chronic wounds.

Area of Science:

  • Wound healing research
  • Immunology
  • Diabetic complications

Background:

  • Proinflammatory mediators drive peripheral-blood mononuclear cells into wound sites.
  • Macrophages exhibit diverse phenotypes crucial for wound healing, adaptable to microenvironmental cues.
  • Diabetic cutaneous environments disrupt macrophage quantity, morphology, and function, impeding wound repair.

Purpose of the Study:

  • To review the intricate relationship between intractable diabetic wounds and macrophage behavior.
  • To explore the potential of exogenous growth factors in modulating macrophage phenotypes for improved diabetic wound healing.

Main Methods:

  • Literature review focusing on macrophage biology in wound healing.
  • Analysis of studies investigating diabetic wound pathophysiology.
  • Examination of research on growth factor supplementation in wound treatment.

Main Results:

  • Macrophage phenotype plasticity is central to wound healing dynamics.
  • Diabetic conditions significantly alter macrophage roles, leading to delayed healing.
  • Exogenous growth factors show promise in normalizing macrophage function.

Conclusions:

  • Understanding macrophage dynamics is key to addressing diabetic wound complications.
  • Targeting macrophage phenotypes with growth factors represents a potential therapeutic strategy for intractable diabetic wounds.

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