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Association between the IL1B, IL1RN polymorphisms and COPD risk: a meta-analysis
Zi-Kang Xie1, Qiu-Pin Huang2, Jian Huang3
11] Department of Clinical Medicine, Grade 2011, Guangxi Medical University, Nanning, China [2].
Scientific Reports
|September 2, 2014
Summary
Interleukin-1 gene variations are linked to chronic obstructive pulmonary disease (COPD) risk, particularly in East Asians. Specific IL1B and IL1RN polymorphisms increase COPD susceptibility in this population.
Area of Science:
- Genetics
- Pulmonology
- Immunology
Background:
- Interleukin-1 (IL-1) gene polymorphisms have been investigated for their potential role in chronic obstructive pulmonary disease (COPD) susceptibility.
- Previous studies have yielded controversial findings regarding the association between IL-1 gene variants and COPD risk.
- A comprehensive meta-analysis is needed to clarify the relationship between IL-1 polymorphisms and COPD.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between specific interleukin-1 (IL-1) gene polymorphisms and the risk of developing chronic obstructive pulmonary disease (COPD).
- To investigate potential ethnic differences in the association between IL-1 gene polymorphisms and COPD risk.
Main Methods:
- A meta-analysis was performed to synthesize data from existing studies on IL-1 gene polymorphisms and COPD.
- Odds ratios (OR) and 95% confidence intervals (CI) were calculated to assess the strength of the association.
- Stratification by ethnicity was employed to explore variations in risk across different populations.
Main Results:
- No overall association was found between IL1B (-511), (-31), and (+3954) polymorphisms and COPD risk across all study subjects.
- However, East Asian populations showed an increased risk of COPD associated with IL1B (-511) T allele carriers and IL1B (-31) C allele carriers.
- A significant association between the IL1RN (VNTR) polymorphism and COPD risk was observed in all subjects and East Asians under a homozygote model.
Conclusions:
- The IL1B (-511), (-31) and IL1RN (VNTR) polymorphisms are associated with an increased risk of COPD specifically in East Asian populations.
- The IL1B (+3954) polymorphism shows no association with COPD risk.
- Further research is recommended to investigate these genetic associations in ethnic groups beyond East Asians.
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