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Related Concept Videos

Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cell Migration01:09

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cytoskeletal Coordination in Cell Migration01:32

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Chemotaxis and Direction of Cell Migration01:21

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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Role of Myosin in Cell Migration01:18

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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
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Cancer Cell Migration through Invadopodia01:35

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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
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Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

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[Collective cell migrations].

Eric Theveneau1, Nicolas David2

  • 1Centre de biologie du développement, unité mixte de recherche 5547, CNRS, université Paul Sabatier ; 118, route de Narbonne, 31400 Toulouse, France.

Medecine Sciences : M/S
|September 2, 2014
PubMed
Summary
This summary is machine-generated.

Cell migration research now focuses on collective cell behavior, not just individual cell movement. This review covers criteria and mechanisms for collective cell migration in tissues.

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Last Updated: Apr 25, 2026

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biophysics

Context:

  • The study of cell migration has evolved from individual cell motility to understanding group dynamics.
  • Collective cell migration is crucial in physiological and pathological processes.
  • Distinguishing collective migration from individual or parallel cell movements is key.

Purpose:

  • To define the criteria for classifying migratory events as collective cell migration.
  • To review fundamental concepts governing collective cell migration in epithelial and mesenchymal tissues.
  • To highlight mechanisms controlling polarity and directionality in cell collectives.

Summary:

  • Collective cell migration involves coordinated movement of cell populations, distinct from solitary or parallel individual cell migration.
  • This review outlines criteria for identifying collective cell migration and discusses its regulation in different tissue types.
  • Key focus areas include the mechanisms governing polarity and directional guidance within cell collectives.

Impact:

  • Provides a framework for understanding complex cell movement in biological systems.
  • Enhances knowledge of tissue development, wound healing, and cancer metastasis.
  • Offers insights into the biophysical and molecular regulation of cell population dynamics.