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Relapsed perinatal neuroblastoma after expectant observation
Ralph Salloum1, Aaron Garrison, Daniel von Allmen
1Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio.
Pediatric Blood & Cancer
|September 2, 2014
Summary
Expectant observation of infants with perinatal neuroblastoma shows excellent survival and avoids surgery for most. However, late recurrence can occur, necessitating long-term surveillance for neuroblastoma patients.
Area of Science:
- Pediatric Oncology
- Neuroblastoma Research
- Clinical Trial Analysis
Background:
- The Children's Oncology Group (COG) ANBL00P2 study evaluated expectant observation for infants with perinatal neuroblastoma.
- Perinatal neuroblastoma presenting as small adrenal masses often has a favorable prognosis.
Observation:
- A 5-year-old female diagnosed with perinatal neuroblastoma was initially managed under the COG ANBL00P2 protocol.
- The patient showed no evidence of disease by nine months of age via ultrasound and biochemical markers.
Findings:
- The patient experienced a late relapse four years after initial diagnosis.
- The relapse presented as high-risk stage 4 MYCN-amplified neuroblastoma, indicated by abdominal pain.
Implications:
- While expectant observation is effective for many infants, long-term surveillance is crucial due to the risk of late recurrence.
- This case highlights the need for continued monitoring in neuroblastoma survivors, even after initial disease remission.
