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Updated: Apr 25, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and antihypertensive activity of novel quinazolin-4(3H)-one derivatives
Seema R Pathak, Vineet Malhotra, Rajendra Nath
1Chemistry Department, Amity School of Applied Sciences, Amity University Haryana. seemarpathak@gmail.com.
Abstract:
A series of novel substituted quinazolin-4(3H)-one derivatives were synthesized and screened in vivo for their antihypertensive activities. Out of eighteen synthesized compounds, seven i.e. 2a, 2c, 4a, 4d, 5d, 6a & 6b compounds have shown hypotensive effect and produced bradycardia. These compounds have shown better activity than reference drug Prazosin (which acts as anti-hypertensive agent by α1 blocking action). All the compounds have shown ALD50>1000mg/kg with maximum in 2c & 4d (>1200mg/kg).
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