Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

6.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

844
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
844
Computed Tomography01:10

Computed Tomography

7.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EXPRESS: Kinetic modeling of the Tropomyosin Receptor Kinases radioligand [<sup>18</sup>F]TRACK in human brain with high-resolution positron emission tomography.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Multimodal mapping of balance dysfunction in Parkinson's disease: a consensus roadmap for research and intervention.

Current opinion in neurology·2026
Same author

Visual Cortical Response Variability in Infants at High Familial Likelihood for Autism.

bioRxiv : the preprint server for biology·2026
Same author

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease.

Research square·2026
Same author

Why We Still Get Back Pain Wrong: Beliefs and Attitudes Towards Low Back Pain Among Austrian Physiotherapists and Healthcare Students: A Cross-Sectional Study.

Musculoskeletal care·2026
Same author

Evaluating structural connectivity disruption after stroke: individual tractography or the use of a model-based approach?

NeuroImage. Clinical·2026
Same journal

Investigating the Neural Origins of Ear-EEG: A Correlation Study Using Scalp EEG Source Reconstruction.

NeuroImage·2026
Same journal

Hysteresis effects in visual and auditory perception and the comparison of underlying neural mechanisms - an EEG study.

NeuroImage·2026
Same journal

Short-term audio-tactile training affects cortical auditory speech-envelope tracking for incongruent but not congruent stimuli.

NeuroImage·2026
Same journal

Dissociable Neurocognitive Mechanisms of State and Trait Anxiety in Working Memory: Threat-Induced Alterations in Decision Dynamics and Attenuation of Large-Scale Network Reconfiguration.

NeuroImage·2026
Same journal

Neuro-Ocular Amyloid Characterization in Alzheimer's Disease via Cross-Site PET-MRI and Hierarchical Cross-Attention Driven Multimodal Representation Learning.

NeuroImage·2026
Same journal

Whole-brain network dynamics underlying intolerance of uncertainty.

NeuroImage·2026
See all related articles

Related Experiment Video

Updated: Apr 25, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

10.9K

Surface-based partial-volume correction for high-resolution PET.

Thomas Funck1, Caroline Paquette2, Alan Evans3

  • 1Montreal Neurological Institute, McGill University, Montreal, Canada; Jewish General Hospital, Montreal Canada.

Neuroimage
|September 2, 2014
PubMed
Summary
This summary is machine-generated.

A new algorithm, idSURF, corrects for partial volume effects (PVE) in positron emission tomography (PET) imaging. This method accurately recovers radiotracer concentrations, offering a validated tool for analyzing PET data, especially in small brain structures.

Keywords:
Cortical thicknessMagnetic resonance imageryPartial-volume correctionPositron emission tomography

More Related Videos

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

7.9K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.2K

Related Experiment Videos

Last Updated: Apr 25, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

10.9K
A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

7.9K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.2K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Neuroscience

Background:

  • Positron emission tomography (PET) measurements are affected by partial volume effects (PVE) due to limited scanner resolution.
  • While high-resolution PET cameras reduce PVE, corrections remain crucial for analyzing small brain structures and subtle neuroreceptor variations.

Purpose of the Study:

  • To develop and validate a novel iterative deconvolution algorithm (idSURF) for partial-volume correction (PVC) of PET images.
  • To overcome limitations of existing PVC methods by incorporating anatomical information and anatomically constrained filtering.

Main Methods:

  • Developed idSURF, an iterative deconvolution algorithm for PET image PVC.
  • Incorporated anatomical information from MRI-derived cortical gray matter surface representations.
  • Utilized anatomically constrained filtering to reduce noise and validated using simulated and clinical PET data against the Geometric Transfer Matrix (GTM) method.

Main Results:

  • Simulated data showed idSURF accurately recovered radiotracer concentrations within 1-5% of true values.
  • Clinical data demonstrated high correlation (R² = 0.99) between idSURF and GTM for radiotracer concentrations and non-displaceable binding potential (BPnd).
  • Errors in clinical data analysis ranged from 0% to 3.2%.

Conclusions:

  • idSURF is a valid and effective method for PVC in PET imaging.
  • The algorithm generates PVE-corrected images and is suitable for automatic processing of large PET datasets.
  • idSURF shows potential for clinical utility in neuroreceptor imaging and analysis of small brain structures.