Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

116
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
116
Pharmacovigilance01:19

Pharmacovigilance

2.0K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
2.0K
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

271
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
271
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

1.9K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.9K
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

290
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
290
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

227
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
227

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Effectiveness of integrated soil-borne nematodiasis and clonorchiasis control programmes in Guizhou Province from 2019 to 2023].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2025
Same author

[Research progress of the prevention, care, and treatment services along the HIV/AIDS care cascade].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2025
Same author

Predicting the 10-year risk of cardiomyopathy in long-term survivors of childhood cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

[Analysis of types and treatment methods of cervical massive hemorrhage].

Zhonghua yi xue za zhi·2021
Same author

Benzodiazepine exposures among women of reproductive age in the US, 2004-2018.

Human & experimental toxicology·2021
Same author

Effects of spatial variation in water quality and hydrological factors on environmental flows.

The Science of the total environment·2020
Same journal

Acute lung injury and progressive pulmonary fibrosis following chlorotrifluoroethylene inhalation: insights from a case.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Suspected serotonin toxicity following combined nefopam and tramadol use in an older adult.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Serum benzylpenicillin levels during treatment for amatoxin poisoning: pharmacokinetic support for OATP1B3 inhibition.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Unlabeled kratom alkaloids detected in products marketed as kava.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Contemporary survey of United States poison center treatment recommendations for sodium channel blocking drug poisoning.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Safety of acetylcysteine: a scoping review of iatrogenic overdose cases and their associated complications.

Clinical toxicology (Philadelphia, Pa.)·2026
See all related articles

Related Experiment Video

Updated: Apr 25, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

11.6K

Medication errors reported to U.S. Poison Control Centers, 2000-2012.

T J Brophy1, H A Spiller, M J Casavant

  • 1The Ohio State University College of Medicine , Columbus, OH , USA.

Clinical Toxicology (Philadelphia, Pa.)
|September 2, 2014
PubMed
Summary
This summary is machine-generated.

Out-of-hospital medication errors are rising nationally, with increasing age-related risks. Analgesics and cardiovascular drugs are frequently involved, highlighting the need for improved medication safety. (36 words)

Keywords:
AnalgesicsCardiovascular drugsPoison Control CentersUnintentional therapeutic errors

More Related Videos

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

33.8K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.7K

Related Experiment Videos

Last Updated: Apr 25, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

11.6K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

33.8K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.7K

Area of Science:

  • Public Health
  • Pharmacovigilance
  • Epidemiology

Background:

  • Previous research on medication errors primarily focused on healthcare facilities.
  • Generalizable national trends in out-of-hospital medication errors remain underreported.
  • Understanding these trends is crucial for public health and patient safety initiatives.

Purpose of the Study:

  • To investigate U.S. national trends in out-of-hospital medication errors.
  • To identify age-related risks associated with medication errors.
  • To determine the most frequently involved medications and their medical outcomes.

Main Methods:

  • Retrospective analysis of the National Poison Data System (NPDS) from 2000-2012.
  • Medication error cases were analyzed by demographics, pharmaceutical class, dosing error type, and medical outcome.
  • Poisson regression was used to analyze trends in medication error rates.

Main Results:

  • The annual out-of-hospital medication error rate increased by 69.8% from 2000 to 2012.
  • Age positively correlated with medication error rates in adults aged 20 and older.
  • Analgesics were most common in younger age groups, while cardiovascular drugs led to injuries in all ages and were most frequent in older adults.

Conclusions:

  • Out-of-hospital medication errors represent a growing public health concern.
  • These errors are a significant source of preventable injury.
  • The increasing incidence underscores the need for targeted prevention strategies.