Related Experiment Video
Updated: Apr 25, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Epithelial remodeling after partial topography-guided normalization and high-fluence short-duration crosslinking
Anastasios John Kanellopoulos1, George Asimellis1
1From Laservision.gr Eye Institute (Kanellopoulos), Athens, Greece, and the New York University Medical School (Kanellopoulos, Asimellis), New York, New York, USA.
Purpose:
To compare epithelial remodeling in keratoconic eyes that had photorefractive keratectomy and corneal collagen crosslinking (Athens protocol) with that in untreated keratoconic eyes and healthy eyes.
Setting:
Private clinical practice, Athens, Greece.
Design:
Comparative case series.
Methods:
Fourier-domain anterior segment optical coherence tomography (AS-OCT) was used to obtain in vivo 3-dimensional epithelial thickness maps and center, superior, inferior, maximum, minimum, mean, midperipheral, and variability data.
Results:
Group A comprised 175 treated keratoconic eyes (Athens protocol); Group B, 193 untreated keratoconic eyes; and Group C, 160 healthy eyes. The 1-year mean center epithelial thickness in Group A was 47.78 μm ± 7.36 (SD) (range 33 to 64 μm). At the first clinical visit, it was 52.09 ± 6.80 μm (range 36 to 72 μm) in Group B and 52.54 ± 3.23 μm (range 45 to 59 μm) in Group C. The mean thickness range in Group A at 1 year was -19.94 ± 7.21 μm (range -6 to -34 μm). It was -21.83 ± 12.07 μm (range -4 to -66 μm) in Group B and -6.86 ± 3.33 μm (range -3 to -29 μm) in Group C. The mean topographic thickness variability in Group A at 1 year was 4.64 ± 1.63 μm (range 1.6 to 8.1 μm) (P<.05). It was 5.77 ± 3.39 μm (range 1.3 to 17.8 μm) in Group B and 1.59 ± 0.79 μm (range 0.6 to 5.6 μm) in Group C.
Conclusion:
Anterior segment OCT indicated a thinner and more homogeneous remodeled epithelium in the keratoconic eyes treated using the Athens protocol.
Financial Disclosure:
Dr. Kanellopoulos is a consultant to Alcon Surgical, Inc.; Wavelight Laser Technologie AG; Avedro, Inc.; and i-Optics Optikgeräte GmbH. Dr. Asimellis has no financial or proprietary interest in any material or method mentioned.
