Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

4.0K
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
4.0K
Ascites01:19

Ascites

22
DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...
22
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.4K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.4K
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

45
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
45
Carrier-Mediated Transport01:06

Carrier-Mediated Transport

1.6K
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
1.6K
Inflammation01:38

Inflammation

46.1K
Overview
46.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary lemon essential oil mitigates metalaxyl-induced oxidative stress, hematological disruptions, and immunotoxicity in Nile tilapia (Oreochromis niloticus) with associated changes in splenic MAPK-and caspase-related gene expression.

Research in veterinary science·2026
Same author

2026 ISPD Position Statement on tracking and reporting loss from PD therapy.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis·2026
Same author

A life course approach to preventing chronic kidney disease by limiting long-term consequences of early adverse events.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Development of 'Location of Dialysis Care in Kidney Life', a service delivery intervention to eliminate unwarranted variation in home dialysis uptake between kidney services and to optimise home dialysis use.

BMC health services research·2026
Same author

Problematic relevance of animal studies on peritoneal vascularization to the clinical practice of peritoneal dialysis.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis·2026
Same author

Fennel essential oil as a natural feed additive to mitigate heat stress in broilers: Effects on growth, physiological and immunological responses, and intestinal morphology.

Journal of thermal biology·2026

Related Experiment Video

Updated: Apr 24, 2026

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery
08:07

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

Published on: October 4, 2024

950

Peritoneal solute transport and inflammation.

Simon J Davies1

  • 1Heath Services Research Unit, Institute for Science and Technology in Medicine, Faculty of Health, Keele University, Stoke-on-Trent, United Kingdom.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|September 2, 2014
PubMed
Summary

Peritoneal solute transport rate (PSTR) measures how fast solutes cross the peritoneal membrane. Intraperitoneal inflammation, not initial membrane differences, significantly impacts PSTR and may lead to fibrosis.

Keywords:
Inflammationencapsulating peritoneal sclerosis (EPS)end-stage renal disease (ESRD)fibrosismembrane functionperitoneal dialysis (PD)peritoneal solute transport rate (PSTR)peritonitissurvivalultrafiltration

More Related Videos

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

9.2K
Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
06:04

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease

Published on: February 9, 2016

21.0K

Related Experiment Videos

Last Updated: Apr 24, 2026

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery
08:07

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

Published on: October 4, 2024

950
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

9.2K
Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
06:04

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease

Published on: February 9, 2016

21.0K

Area of Science:

  • Nephrology
  • Peritoneal Dialysis
  • Membrane Physiology

Background:

  • Peritoneal solute transport rate (PSTR) is crucial for assessing peritoneal membrane function in dialysis.
  • PSTR is clinically validated for predicting patient survival and membrane changes.
  • Dialysis modality and prescription decisions are influenced by PSTR measurements.

Observation:

  • Intraperitoneal inflammation, indicated by local interleukin 6, is a key PSTR determinant.
  • This inflammation is often independent of systemic inflammation and its associated mortality risks.
  • High PSTR may not stem from inherent membrane differences but rather a spectrum influenced by genetics.

Findings:

  • Persistent or increasing PSTR suggests ongoing intraperitoneal inflammation.
  • This sustained inflammation is linked to the progression of peritoneal membrane fibrosis.
  • The 4-hour dialysate to plasma creatinine ratio serves as a practical PSTR approximation.

Implications:

  • Understanding PSTR determinants is vital for optimizing peritoneal dialysis.
  • Targeting intraperitoneal inflammation could prevent membrane fibrosis progression.
  • PSTR monitoring aids in personalized dialysis prescriptions and improved patient outcomes.