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Updated: Apr 24, 2026

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
Gray matter alteration in patients with restless legs syndrome: a voxel-based morphometry study
Yongmin Chang1, Hyuk Won Chang2, Huijin Song3
1Department of Molecular Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.
Abstract:
The purpose of this study was to demonstrate whether or not restless legs syndrome (RLS) is associated with any morphological change in gray matter. Forty-six RLS subjects and 46 controls were enrolled. We performed voxel-based morphometry analysis and compared the results of the two groups. The RLS subjects showed significant regional decreases of gray matter volume in the left hippocampal gyrus, both parietal lobes, medial frontal areas and cerebellum (uncorrected, P<.001). We found that RLS patients showed structural alteration in the brain and alterations in certain parts of the brain in RLS patients are relevant to RLS.
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