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Published on: July 14, 2016
[Histidine triad nucleotide-binding protein 1 and human diseases]
Yong-hui Dang1, Zhong-wei Liu2, Feng Chen3
1College of Medicine & Forensics,Xi'an Jiaotong University Health Science Center,Key Laboratory of the Health Ministry for Forensic Medicine,Key Laboratory of Environment and Genes Related to Diseases of the Education Ministry,Xi'an 710061,China.
Abstract:
Histidine triad nucleotide-binding protein 1 (HINT1) is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx, in which x represents hydrophobic amino acid. HINT1 is implicated in pathological progress of many human diseases including cancer and schizophrenia; however, little is known about the essential role and pathological consequences of HINT1 in cellular physiology and diseases. Therefore, we summarize the structure, distribution, and physiological function of HINT1 in cells and tissues as well as the correlation between HINT1 and human diseases.
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