Disintegrants combination: development and optimization of a cefadroxil fast disintegrating tablet

Area of Science:

• Pharmaceutical Technology
• Drug Delivery Systems
• Formulation Science

Background:

• Fast disintegrating tablets (FDTs) offer advantages for specific patient populations and improved bioavailability.
• Optimizing FDTs is crucial for enhancing patient compliance and therapeutic efficacy.
• Cefadroxil is an antibiotic that can benefit from improved dosage form design.

Purpose of the Study:

• To design and optimize cefadroxil fast disintegrating tablets (FDTs).
• To evaluate the impact of croscarmellose and crospovidone on FDT properties.
• To identify a formulation with optimal pharmacotechnical attributes and enhanced bioavailability.

Main Methods:

• Utilized central composite design with croscarmellose and crospovidone as independent variables.
• Employed Design-Expert software for optimization and response surface analysis.
• Assessed various pharmacopeial and non-pharmacopeial parameters for tablet quality.

Main Results:

• Formulations F3, F8, and F9 exhibited promising results.
• Formulation F9, containing 15mg croscarmellose and 33.075mg crospovidone, showed excellent pharmacotechnical attributes and stability.
• F9 demonstrated rapid dissolution, with 90% drug release (t90%) in over 2 minutes.

Conclusions:

• The optimized cefadroxil FDT formulation (F9) possesses favorable characteristics for pharmaceutical application.
• The study successfully identified optimal levels of disintegrants for cefadroxil FDTs.
• The developed FDTs are expected to improve cefadroxil bioavailability and patient compliance.