Formulation and stability evaluation of immediate release antioxidant tablet

Area of Science:

• Pharmaceutical Sciences
• Nutritional Biochemistry
• Oxidative Stress Research

Background:

• Oxidative stress is implicated in numerous human diseases, necessitating effective pharmaceutical interventions.
• Developing novel formulations to mitigate oxidative damage and its health consequences is crucial.
• Antioxidants play a vital role in combating cellular damage caused by free radicals.

Purpose of the Study:

• To design and evaluate a rapidly releasing synthetic antioxidant tablet.
• To combine key antioxidants (Vitamins A, C, E) with zinc and lecithin for enhanced efficacy.
• To conduct stability studies to ensure long-term quality and shelf-life.

Main Methods:

• Formulation of an immediate-release tablet using the wet granulation method.
• Inclusion of specific excipients like Avicel pH 102, pregelatinized starch, and colloidal silicon dioxide.
• Utilizing Vitamin C as a tracer for tablet evaluation and employing USP 24 / NF 19, 2000 guidelines.

Main Results:

• Successful development of three distinct tablet formulations.
• Evaluation confirmed the tablet dosage form meets quality standards.
• Stability studies indicated the formulation's quality is maintained over a 24-month storage period.

Conclusions:

• The designed rapidly releasing antioxidant tablet formulation is stable and effective.
• This formulation can potentially meet human health and nutritional requirements.
• The study provides a viable pharmaceutical strategy against oxidative stress-related conditions.