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Conformational analysis and geometry optimization of buspirone-A 5-HT1A receptor agonist
Huma Ikram1, Muhammad Azhar2, Muhammad Jameel2
1Department of Biochemistry, University of Karachi, Karachi, Pakistan.
Abstract:
Buspirone, a partial 5-HT1A receptor agonist, is a clinically prescribed anxiolytic. In the present study, conformational analysis and geometry optimization of buspirone were done as per Hartree-Fock (HF) calculation method by Argus Lab 4.0.1 software. The minimum potential energy was calculated by geometry convergence function by Argus Lab software. The results indicate that the best conformation of molecule is present at minimum potential energy of-100679.5513 kcal/mol. At this point, buspirone will be more active.
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