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[Neuroprotective treatment of chronic cerebrovascular insufficiency]

A V Anisimova, T I Kolesnikova, E V Iutskova

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |September 2, 2014
    PubMed

    Insights

    Cerebrolysin improved blood flow in patients with chronic brain ischemia by enhancing erythrocyte properties. This treatment positively impacts neurological and cognitive functions in these patients.

    Area of Science:

    • Neurology
    • Hematology

    Background:

    • Chronic brain ischemia (CBI) affects neurological and cognitive functions.
    • CBI is classified into stages I and II.
    • Effective treatments for CBI are crucial for improving patient outcomes.

    Purpose of the Study:

    • To evaluate the efficacy of cerebrolysin in patients with chronic brain ischemia (CBI) stages I and II.
    • To investigate the effects of cerebrolysin on neurological, emotional, and cognitive status.
    • To assess cerebrolysin's impact on hemorheological parameters, including erythrocyte aggregation and deformity.

    Main Methods:

    • A study involving 300 patients with CBI, divided into stage I (195 patients) and stage II (105 patients).
    • A control group of 45 patients did not receive cerebrolysin.
    • Assessment included neurological and emotional status, cognitive functions, and hemorheological indicators (platelet and erythrocyte aggregation, deformity, morpho-densitometric parameters).

    Main Results:

    • Cerebrolysin administration led to improvements in neurological and emotional status.
    • Cognitive functions showed positive changes following cerebrolysin treatment.
    • The study identified enhanced morpho-densitometric characteristics of erythrocytes and improved hemorheological properties, crucial for capillary blood flow.

    Conclusions:

    • Cerebrolysin demonstrates efficacy in treating chronic brain ischemia stages I and II.
    • The drug positively influences cognitive and neurological functions.
    • Additional mechanisms of cerebrolysin action involve improving erythrocyte deformability and hemorheological parameters, vital for microcirculation.
    Abstract

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