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[Changes in AI, B and E apolipoproteins induced by infusion of lipid emulsions in critical patients]
In 24 critically ill patients HDL, LDL and VLDL values and those of apolipoproteins (apo) AI, B and E were evaluated just before (T0) and after 1 (T1), 3 (T3), 5 (T5) hours of intralipid infusion. Baseline levels of such parameters were compared with those obtained in 26 healthy volunteers. The critically ill patients showed lower values of apo AI and B (p less than 0.001) than control patients. In intensive care unit patients, a close relationship between HDL and apo AI (p less than 0.001) and between LDL and apo B (p less than 0.001) was observed in addition to the evidence of apo B and E interconversion. In fact, these apolipoproteins were always significantly correlated (p less than 0.01 a T0 e T3; p less than 0.001 a T1; p less than 0.05 a T5). The knowledge of the apolipoproteins functions could be important for the understanding and the detection of the negative effects that could follow to the infusion of fat emulsions.
In 24 critically ill patients HDL, LDL and VLDL values and those of apolipoproteins (apo) AI, B and E were evaluated just before (T0) and after 1 (T1), 3 (T3), 5 (T5) hours of intralipid infusion. Baseline levels of such parameters were compared with those obtained in 26 healthy volunteers. The critically ill patients showed lower values of apo AI and B (p less than 0.001) than control patients. In intensive care unit patients, a close relationship between HDL and apo AI (p less than 0.001) and between LDL and apo B (p less than 0.001) was observed in addition to the evidence of apo B and E interconversion. In fact, these apolipoproteins were always significantly correlated (p less than 0.01 a T0 e T3; p less than 0.001 a T1; p less than 0.05 a T5). The knowledge of the apolipoproteins functions could be important for the understanding and the detection of the negative effects that could follow to the infusion of fat emulsions.