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[Glucocorticoid and Bone. Fracture risk of steroid-induced osteoporosis]
1Health Management & Promotion Center, Hiroshima Atomic Bomb Casualty Council, Japan.
Abstract:
Bone loss occurred early after starting oral glucocorticoid (GC) therapy and the risk of fracture increased rapidly within 3 to 6 months. Fracture risk decreased rapidly after stopping GC therapy. Strong relationships were found between cumulative dose of GC and loss of BMD and between daily dose and fracture risk. Short term use, intermittent use, and inhaled use of higher dose of GC increased fracture risk. There are insufficient data to determine if short term use, intermittent use, or inhaled use of lower dose of GC increased the fracture risk.
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