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[Glucocorticoid and Bone. Osteocytic osteolysis : potential modulation by glucocorticoids]
1Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Japan.
Clinical Calcium
|September 2, 2014
Summary
Glucocorticoids cause bone loss by affecting bone cells. Osteocytic osteolysis, where osteocytes dissolve bone, may contribute to glucocorticoid-induced osteoporosis and offer new treatment targets.
Area of Science:
- Bone biology and osteoporosis research.
- Cellular mechanisms of bone remodeling.
- Endocrinology and metabolic bone diseases.
Context:
- Glucocorticoid-induced osteoporosis is a significant side effect of corticosteroid therapy.
- Osteocytes, embedded within the bone matrix, form a communication network throughout the bone.
- Osteocytic osteolysis, the dissolution of bone matrix by osteocytes, is a recognized phenomenon.
Purpose:
- To explore the role of osteocytic osteolysis in the pathogenesis of glucocorticoid-induced osteoporosis.
- To investigate how glucocorticoids influence osteocyte function and perilacunar remodeling.
- To evaluate the potential of targeting osteocytic osteolysis for osteoporosis treatment.
Summary:
- Glucocorticoids impair bone formation and induce osteocyte apoptosis, contributing to osteoporosis.
- Glucocorticoids increase osteocyte lacunae size and enhance perilacunar remodeling, suggesting a role for osteocytic osteolysis.
- This review examines the contribution of osteocytic osteolysis to glucocorticoid-induced osteoporosis using mouse models.
Impact:
- Understanding osteocytic osteolysis could reveal novel therapeutic strategies for glucocorticoid-induced osteoporosis.
- Identifying the mechanisms by which osteocytes contribute to bone loss may lead to targeted treatments.
- This research could improve patient outcomes for individuals on long-term corticosteroid therapy.
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