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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response I: Vascular and Cellular01:30

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Chronic Inflammation: Introduction01:12

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Introduction to Lymphatic and Immune System01:23

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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
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Acute Inflammation I: Inflammatory Response01:26

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Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect...
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Inflammation01:38

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Related Experiment Video

Updated: Apr 24, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
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Interplay between Inflammatory Responses and Lymphatic Vessels.

Kihyuk Shin1, Seung-Hyo Lee2

  • 1Department of Medicine, Pusan National University Hospital, Busan 602-739, Korea. ; Graduate School of Medical Science and Engineering, and Biomedical Research Center, and KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.

Immune Network
|September 2, 2014
PubMed
Summary
This summary is machine-generated.

Inflammation actively promotes lymphatic vessel growth (lymphangiogenesis) and influences immune cell behavior. This review explores how inflammatory cytokines impact lymphangiogenesis and the immune roles of lymphatic vessels.

Keywords:
Immune responsesInflammationLymphangiogenesisLymphatic vessels

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Area of Science:

  • Immunology
  • Vascular Biology
  • Cell Biology

Background:

  • Lymphatic vessels facilitate leukocyte migration and fluid balance.
  • Emerging evidence highlights their active role in immune regulation.
  • Tissue inflammation triggers lymphatic endothelial cell proliferation and chemokine release, leading to lymphangiogenesis.

Purpose of the Study:

  • To review the impact of inflammatory cytokines on lymphangiogenesis.
  • To examine the role of lymphatic vessels in modulating immune responses.

Main Methods:

  • Literature review of current research on lymphangiogenesis and immune regulation by lymphatic vessels.
  • Analysis of the mechanisms by which lymphatic endothelial cells influence T cell tolerance.

Main Results:

  • Inflammatory cytokines are key drivers of lymphangiogenesis.
  • Lymphatic endothelial cells actively participate in immune regulation, including T cell tolerance induction.
  • Lymphatic vessels play a dynamic role in modulating inflammatory and immune responses.

Conclusions:

  • Lymphatic vessels are crucial active participants in immune responses, not just passive conduits.
  • Understanding the interplay between inflammation, lymphangiogenesis, and immune modulation is vital for therapeutic strategies.