Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.1K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.1K
Metastasis02:30

Metastasis

5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From tumor regression grading to interpretable endpoints in neoadjuvant oncology.

NPJ precision oncology·2026
Same author

The prognostic value of tumour budding for survival in stage II and III colorectal cancer: a systematic review and meta-analysis.

Histopathology·2026
Same author

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization.

Molecular oncology·2026
Same author

MetAssist 2.0: A Generalizable Artificial Intelligence Framework for Lymph Node Metastasis Detection Across Multiple Cancer Types.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same author

A comprehensive European Colorectal Cancer Cohort dataset.

Scientific data·2026
Same author

What practicing pathologists and oncologists should know about the new computational pathology-based companion diagnostic tools.

The Journal of pathology·2026

Related Experiment Video

Updated: Apr 24, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

9.5K

Tumor budding in upper gastrointestinal carcinomas.

Viktor H Koelzer1, Rupert Langer1, Inti Zlobec2

  • 1Clinical Pathology Division, Institute of Pathology, University of Bern , Bern , Switzerland ; Translational Research Unit, Institute of Pathology, University of Bern , Bern , Switzerland.

Frontiers in Oncology
|September 2, 2014
PubMed
Summary

Tumor budding (TB) is a key indicator of poor prognosis in gastrointestinal cancers. This review analyzes TB

Keywords:
epithelial–mesenchymal transitionesophageal cancergastric cancergastrointestinal cancerprognostic factortumor buddingtumor microenvironment

More Related Videos

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
06:43

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib

Published on: April 3, 2026

137
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.4K

Related Experiment Videos

Last Updated: Apr 24, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

9.5K
Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
06:43

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib

Published on: April 3, 2026

137
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.4K

Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Personalized medicine in oncology relies on predicting individual relapse and death risks.
  • Tumor budding (TB) at the tumor-host interface signifies unfavorable disease biology in gastrointestinal cancers.
  • TB, defined as small cell clusters at the invasive front, is linked to advanced stage and metastasis.

Purpose of the Study:

  • To provide a comprehensive analysis of tumor budding (TB) in upper gastrointestinal cancers.
  • To critically appraise the perspectives for further study on TB in clinical practice.
  • To highlight the prognostic significance of TB in various gastrointestinal malignancies.

Main Methods:

  • Literature review and critical appraisal of existing studies on tumor budding.
  • Analysis of TB's correlation with clinicopathological features and patient outcomes.
  • Examination of current challenges and future directions for TB assessment.

Main Results:

  • Tumor budding (TB) is a recognized prognostic factor in colon and rectal cancers by the UICC.
  • TB shows promise as a prognostic indicator for esophageal, gastro-esophageal junction, and gastric adenocarcinomas.
  • TB presence consistently correlates with advanced tumor stage, lymphovascular invasion, and metastasis.

Conclusions:

  • Standardization of TB assessment methods and validation in large studies are crucial for daily practice.
  • Inter-observer reproducibility needs to be addressed for reliable TB evaluation.
  • Further research is essential to fully integrate TB into the clinical management of gastrointestinal cancers.