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Granulocytic sarcoma with compressive myelopathy: a rare presentation of chronic myelogenous leukemia

Abhijeet P Ganapule1, Auro Viswabandya2, Anita Jasper3

  • 1Assistant Professor, Department of Haematology, Christian Medical College and Hospital , Vellore, Tamil Nadu, India .

Journal of Clinical and Diagnostic Research : JCDR
|September 2, 2014
PubMed

Granulocytic sarcoma occurs most commonly in acute myelogenous leukemia. The appearance of granulocytic sarcoma in chronic myelogenous leukemia signals accelerated phase/ blast transformation. This is a rare case of undiagnosed chronic myelogenous leukemia with granulocytic sarcoma causing cord compression, which went into tumour lysis syndrome requiring dialysis after starting of steroids and radiotherapy. A 43-year-old male presented in emergency department with acute onset of flaccid paralysis. On clinical examination, there was hepatosplenomegaly and lower motor neuron paralysis in the lower limbs. The peripheral smear was consistent with chronic myelogenous leukemia in chronic phase. The MRI spine revealed para-spinal and epidural masses causing cord compression and the biopsy from the paraspinal mass was consistent with granulocytic sarcoma.

Keywords:
Cord compressionGranulocytic sarcomaTumour lysis syndrome

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