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06:01
Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
Published on: October 6, 2022
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Signalling molecules in the urothelium.
Michael Winder1, Gunnar Tobin1, Daša Zupančič2
1Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 13, 405 30 Gothenburg, Sweden.
Biomed Research International
|September 2, 2014
Summary
The urothelium, once seen as a passive barrier, is now known to sense the bladder environment by releasing signaling molecules like acetylcholine and ATP. This review explores these dynamic urothelial functions in health and disease.
Area of Science:
- Urology
- Cell Biology
- Physiology
Background:
- The urothelium was traditionally viewed as a passive protective layer.
- Emerging evidence highlights its active role in sensing the intravesical environment.
Purpose of the Study:
- To review current knowledge on urothelial signaling molecules.
- To discuss the formation, release, and effects of key signaling molecules in health and disease.
Main Methods:
- Literature review of recent research on urothelial function.
- Synthesis of information on signaling pathways involving acetylcholine, ATP, adenosine, and nitric oxide.
Main Results:
- The urothelium actively releases signaling molecules (acetylcholine, ATP, adenosine, nitric oxide).
- These molecules act in autocrine and paracrine manners within the urinary bladder.
- Urothelial signaling is a critical component of the bladder's sensory network.
Conclusions:
- The urothelium is an integral part of a complex sensory web in the urinary bladder.
- Understanding urothelial signaling is crucial for comprehending bladder function and dysfunction.
- Dysregulation of these signaling pathways may contribute to various bladder pathologies.
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