Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

2.6K
Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
2.6K
Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

2.3K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
2.3K
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

1.8K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
1.8K
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

3.1K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel antibody against CD300c ameliorates cognitive deficits and reduces pathology in the late-stage of APP/PS1 mouse model.

Journal of Alzheimer's disease : JAD·2026
Same author

KARIs, Ghrelin Receptor Agonists With Excellent Brain Permeability, Increase Food Intake and Attenuate the Muscle Loss in Mice.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Augmenting Nrf2 signaling pathway promotes adipocyte differentiation from human embryonic stem cells.

Experimental cell research·2026
Same author

Size Effect of Stem Cell Spheroids in Their Cryopreservation Using Low-Molecular-Weight PEGs as a Cryoprotectant.

Biomaterials research·2026
Same author

Plasma acid sphingomyelinase activity in sepsis: diagnostic utility and association with disease severity.

Critical care (London, England)·2025
Same author

Tyr-Tyr-Glu Tripeptide for Regeneration of Articular Cartilage through Chondrogenic Differentiation of Mesenchymal Stem Cells.

Biomaterials research·2025
Same journal

Hydration Effect of Glycopolymers on Lectin Recognition.

Biomacromolecules·2026
Same journal

Preparation of Permeable Polymersomes for Biomedical Applications.

Biomacromolecules·2026
Same journal

Navigating the Forest of Lignin-Derived Monomers for Polymer Synthesis.

Biomacromolecules·2026
Same journal

Degradable Cationic Polyesters with Tunable Anion-Induced Upper Critical Solution Temperature Coacervation.

Biomacromolecules·2026
Same journal

Understanding Lignin Radical Dynamics: Quenching Radicals by Solvent and Thermal Induced Mobility.

Biomacromolecules·2026
Same journal

Anomalous Diffusion of Nanoparticles in Semidilute Hyaluronic Acid Solutions.

Biomacromolecules·2026
See all related articles

Related Experiment Video

Updated: Apr 24, 2026

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

8.6K

Ion and temperature sensitive polypeptide block copolymer.

Jae Hee Joo1, Du Young Ko, Hyo Jung Moon

  • 1Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, Korea.

Biomacromolecules
|September 3, 2014
PubMed
Summary
This summary is machine-generated.

This study synthesized a dual stimuli-responsive polymer, finding that copper ions significantly enhance its thermogelation due to strong binding affinity. This highlights the importance of ion-polymer interactions in designing responsive materials.

More Related Videos

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

12.8K
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

5.2K

Related Experiment Videos

Last Updated: Apr 24, 2026

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

8.6K
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

12.8K
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
08:09

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

Published on: August 6, 2019

5.2K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials

Background:

  • Development of dual stimuli-responsive polymers is crucial for advanced applications.
  • Poly(ethylene glycol)/poly(L-alanine) multiblock copolymers offer tunable properties.
  • Metal ion complexation can modulate polymer behavior.

Purpose of the Study:

  • To synthesize a poly(ethylene glycol)/poly(L-alanine) multiblock copolymer incorporating ethylene diamine tetraacetic acid ([PA-PEG-PA-EDTA(m)).
  • To investigate the effect of different metal ions (Cu(2+), Zn(2+), Ca(2+)) on the thermogelation of the polymer.
  • To understand the relationship between metal ion binding affinity and thermogelation properties.

Main Methods:

  • Synthesis of [PA-PEG-PA-EDTA(m) multiblock copolymer.
  • Investigation of metal ion effects using techniques like atomic force microscopy (AFM), dynamic light scattering (DLS), and circular dichroism (CD) spectroscopy.
  • Determination of dissociation constants for metal ion-copolymer interactions.

Main Results:

  • The multiblock copolymer exhibited varying binding affinities for different metal ions, with Cu(2+) showing the strongest interaction (Kd = 1.2 × 10(-7) M).
  • Metal ion complexation induced micelle formation and subsequent aggregation with increasing temperature.
  • Cu(2+) ions significantly lowered the thermogelation temperature and increased gel modulus compared to Zn(2+) and Ca(2+), correlating with stronger binding and altered secondary structure.

Conclusions:

  • Strong ionic complexation between Cu(2+) and the multiblock copolymer facilitates thermogelation via salt-bridge formation.
  • The binding affinity of metal ions for polymers is a critical factor in designing effective ion/temperature dual stimuli-responsive systems.
  • This research provides insights into tailoring polymer responses for specific ion concentrations and types.