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Hepatocellular carcinoma after danazol treatment for hereditary angio-oedema
A E M Berkel1, D E Bouman, M R Schaafsma
1Department of Surgery, Medisch Spectrum Twente, Enschede, the Netherlands.
Abstract:
Hereditary angio-oedema is characterised by recurrent episodes of laryngeal, intra-abdominal, facial or peripheral oedema. Danazol can be used as prophylaxis for recurrent attacks. Hepatotoxicity is a recognised adverse effect of danazol. We report an exceptional case of a danazol-induced hepatocellular carcinoma in a 75-year-old patient with hereditary angio-oedema.
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