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A Photonic System for Generating Unconditional Polarization-Entangled Photons Based on Multiple Quantum Interference

A Photonic System for Generating Unconditional Polarization-Entangled Photons Based on Multiple Quantum Interference

Published on: September 5, 2019

High-throughput time-correlated single photon counting.

Jérémie Léonard¹, Norbert Dumas, Jean-Pascal Caussé

¹IPCMS, Institut de Physique et Chimie des Matériaux de Strasbourg, Université de Strasbourg, CNRS UMR 7504, F-67034 Strasbourg Cedex 2, France. Jeremie.Leonard@ipcms.unistra.fr.

|September 3, 2014

Summary

This summary is machine-generated.

Time-correlated single photon counting (TCSPC) enables accurate fluorescence lifetime (FLT) measurements in microfluidic droplets. High-throughput analysis exceeding 1 kHz is achievable, advancing biotechnological applications.

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Area of Science:

Biotechnology
Analytical Chemistry
Microfluidics

Background:

Accurate fluorescence lifetime (FLT) measurements are crucial for biomolecular interaction assays.
High-throughput analysis is limited by photon acquisition rates in single photon detection techniques.

Purpose of the Study:

To demonstrate time-correlated single photon counting (TCSPC) in microfluidic droplets under high-throughput conditions.
To assess the feasibility of FLT measurements at throughputs exceeding 1 kHz.

Main Methods:

Utilizing microfluidic droplets for high-throughput sample handling.
Implementing time-correlated single photon counting (TCSPC) for fluorescence lifetime measurements.

Main Results:

Demonstrated TCSPC in microfluidic droplets at throughputs exceeding 1 kHz.
Achieved accurate FLT measurements despite limitations in photon acquisition rate.
Showcased remarkable sensitivity in fluorescence lifetime detection.

Conclusions:

High-throughput FLT measurements in microfluidic droplets are feasible.
This technique supports innovative biomolecular interaction assays.
Enables high-throughput screening and cell sorting applications in biotechnology.