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Low serum 25-hydroxyvitamin D levels and bronchiolitis severity in Spanish infants

Gloria Moreno-Solís1, Fernando Fernández-Gutiérrez, Javier Torres-Borrego

  • 1Reina Sofía Children's Hospital, Avda Menéndez Pidal S/N, 14004, Córdoba, Spain, gloriamorenosolis@gmail.com.

European Journal of Pediatrics
|September 3, 2014
PubMed

Insights

Infants with acute bronchiolitis have a high prevalence of vitamin D deficiency (hypovitaminosis D). Lower vitamin D levels correlate with increased severity of infant bronchiolitis.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Infectious Diseases

Background:

  • Bronchiolitis is a common respiratory infection in infants.
  • Vitamin D plays a crucial role in immune function.
  • Hypovitaminosis D is prevalent in various pediatric populations.

Purpose of the Study:

  • To determine the prevalence of hypovitaminosis D in infants with acute bronchiolitis.
  • To compare vitamin D levels in infants with bronchiolitis versus healthy controls.
  • To investigate the association between serum 25-hydroxyvitamin D levels and bronchiolitis severity.

Main Methods:

  • Cross-sectional study design.
  • Radioimmunoassay measurement of serum 25-hydroxyvitamin D (25(OH)D) levels.
  • Comparison between 48 infants with acute bronchiolitis and 30 healthy control infants.

Main Results:

  • Infants with acute bronchiolitis had significantly lower 25(OH)D levels compared to controls (median 29.9 vs 38.2 ng/ml, p=0.022).
  • The prevalence of hypovitaminosis D was higher in infants with bronchiolitis (52.1%) than in controls (26.6%).
  • A significant inverse correlation was observed between 25(OH)D levels and bronchiolitis severity (rho=-0.457, p<0.001).

Conclusions:

  • Hypovitaminosis D is highly prevalent in Spanish infants diagnosed with bronchiolitis.
  • Decreased serum 25(OH)D levels are associated with increased severity of acute bronchiolitis in infants.
Abstract

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