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Published on: February 27, 2020
The multicomponent Hantzsch reaction: comprehensive mass spectrometry monitoring using charge-tagged reagents
Vanessa G Santos1, Marla N Godoi, Thaís Regiani
1ThoMSon Mass Spectrometry Laboratory, Instituto de Química, State University of Campinas, 13084-971, Campinas-SP (Brazil).
Abstract:
A novel strategy for the ESI-MS monitoring of reaction solutions involving the alternate use of permanently charge-tagged reagents has been used for comprehensive mass spectrometry monitoring of the multicomponent Hantzsch 1,4-dihydropyridine reaction. By placing a charge tag on either, or both, of the two key reactants, ion suppression effects for ESI were eliminated or minimized, and comprehensive detection of charge-tagged intermediates was achieved. The strategy allowed the trapping and characterization of the important intermediates in the mechanism for 1,4-dihydropyridine formation.
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