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Motor and memory testing of long-lived pregnancy-associated plasma protein--a knock-out mice
Emily J Mason1, Jacquelyn A Grell1, Sally A West1
1Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic, 200 First Street SW, 5-194 Joseph, Rochester, MN55905, USA.
Unlabelled:
Mice deficient in pregnancy-associated plasma protein-A (PAPP-A), an IGF binding protein protease, have been shown to be resistant to experimentally induced atherosclerosis and diabetic nephropathy, and, in the laboratory environment, live 30-40% longer than wild-type littermates in association with delayed incidence and occurrence of age-related neoplasms and degenerative diseases.
Objective:
PAPP-A is highly expressed in the cerebellum and hippocampus of the mouse brain. Therefore, the studies presented here were aimed at determining motor behavior, learning and retention in PAPP-A knock-out (KO) mice compared to wild-type (WT) littermates with age.
Design:
Balance and coordination were assessed using an accelerating rotarod; learning and memory were assessed in a Stone T-maze.
Results:
Time on the rotarod decreased with age but there was no significant difference between PAPP-A KO and WT mice at any of the testing ages. Latency to reach the goal box and number of errors committed in the Stone T-maze did not change with age and there were no significant differences between PAPP-A KO and WT mice.
Conclusion:
Lack of PAPP-A in mice did not impact central regulation of coordination, learning or memory.
