Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

407
Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
407
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

627
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
627
Randomized Experiments01:13

Randomized Experiments

6.3K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
6.3K
Clinical Trials01:16

Clinical Trials

8.5K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
8.5K
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

1.6K
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
1.6K
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

413
Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
413

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the changes in household purchases of foods and drinks high in fat, salt and sugar following Bristol's outdoor advertisement restrictions policy: a quasi-experimental study.

BMJ public health·2026
Same author

De-implementation of healthcare interventions post-COVID-19: evidence from the Evidence-Based Interventions (EBI) programme in England.

BMJ open·2026
Same author

Exploring spillover effects following surgical de-implementation: an observational evaluation of primary care, referrals, and time to surgical intervention following reductions in the use of tonsillectomy and Dupuytren's contracture.

Implementation science communications·2026
Same author

Effectiveness of an environmental nutrition and physical activity intervention in early childhood education and care settings (NAPSACC UK): a multicentre cluster randomised controlled trial.

The Lancet regional health. Europe·2026
Same author

Development and Pretesting of the Children and Young People's Time-Use Questionnaire for Use in Economic Evaluation.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2026
Same author

Demonstrating the value for money of implementing evidence-based treatment: the case for further investment in magnesium sulphate as a neuroprotectant for preterm births.

Frontiers in health services·2026
Same journal

The economic burden of MASH: comparison of healthcare resource utilization and costs in patients with probable MASH, without MASH, and with diagnosed MASH.

Expert review of pharmacoeconomics & outcomes research·2026
Same journal

Comparative landscape of artificial intelligence-assisted systematic literature reviews.

Expert review of pharmacoeconomics & outcomes research·2026
Same journal

Single versus multiple inhaler triple therapy in COPD using data from the pragmatic INTREPID trial: cost-effectiveness analysis from the Chilean public healthcare system perspective.

Expert review of pharmacoeconomics & outcomes research·2026
Same journal

Real-world direct medical costs and resource utilization of immune checkpoint inhibitors in advanced NSCLC with COPD: a multicenter cost-consequence analysis from Iraq.

Expert review of pharmacoeconomics & outcomes research·2026
Same journal

TENS in chronic pain management: a 11-year nationwide analysis using the French National Health Data System.

Expert review of pharmacoeconomics & outcomes research·2026
Same journal

Economic burden of breast cancer in Cyprus from a societal perspective.

Expert review of pharmacoeconomics & outcomes research·2026
See all related articles

Related Experiment Video

Updated: Apr 24, 2026

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

5.2K

Methodological developments in randomized controlled trial-based economic evaluations.

Joanna C Thorn1, Sian M Noble, William Hollingworth

  • 1MRC ConDuCT Hub, School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.

Expert Review of Pharmacoeconomics & Outcomes Research
|September 3, 2014
PubMed
Summary
This summary is machine-generated.

Health economic evaluations alongside randomized controlled trials provide real-world evidence for healthcare decisions. Methodological improvements are needed in trial design, resource use measurement, outcome assessment, and reporting for reliable economic evaluations.

Keywords:
EQ-5Dclinical trialcosteconomic evaluationhealth-related quality of liferandomised controlled trialresource-use measurementutility measurement

More Related Videos

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.3K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.4K

Related Experiment Videos

Last Updated: Apr 24, 2026

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

5.2K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.3K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.4K

Area of Science:

  • Health economics
  • Clinical trial methodology
  • Evidence-based healthcare

Background:

  • Economic evaluations are crucial for healthcare decision-making.
  • Studies alongside randomized controlled trials (RCTs) generate essential real-world evidence.
  • Integrating economic data collection into RCTs presents methodological challenges.

Purpose of the Study:

  • To review methodological advancements in economic evaluations conducted alongside RCTs.
  • To identify areas for improvement in the design and execution of such studies.

Main Methods:

  • Literature review of methodological work.
  • Discussion of recent advances in key areas relevant to economic evaluations in RCTs.

Main Results:

  • Advances have been made in overall trial design for economic evaluations.
  • Improvements are noted in methods for measuring resource use and outcomes within trials.
  • Progress in reporting standards for economic evaluations alongside RCTs has been observed.

Conclusions:

  • Continued methodological development is vital for robust economic evaluations in healthcare.
  • Addressing complexities in resource use and outcome measurement enhances the reliability of real-world evidence from RCTs.
  • Standardized reporting is essential for the effective use of economic evaluations in healthcare policy.