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Related Concept Videos

Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Introduction01:26

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Gastrointestinal involvement in systemic sclerosis.

Edoardo Savarino1, Manuele Furnari2, Nicola de Bortoli3

  • 1Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Presse Medicale (Paris, France : 1983)
|September 3, 2014
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Summary
This summary is machine-generated.

Systemic sclerosis (SSc) frequently affects the gastrointestinal tract, causing significant quality of life issues. Early detection of these gastrointestinal issues in SSc patients is crucial for preventing complications like malnutrition.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Rheumatology

Background:

  • Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by abnormal microvascular, muscular, and immunological functions.
  • SSc leads to progressive connective tissue deposition in the skin and internal organs.
  • The gastrointestinal (GI) tract is the most affected organ after the skin in SSc patients, with up to 80% experiencing GI involvement.

Purpose of the Study:

  • To highlight the significant impact of gastrointestinal involvement in systemic sclerosis.
  • To emphasize the range and severity of GI manifestations in SSc.
  • To underscore the importance of early detection for managing SSc-related GI complications.

Main Methods:

  • Review of existing literature on gastrointestinal manifestations in systemic sclerosis.
  • Analysis of the clinical presentation and impact of GI involvement in SSc patients.
  • Evaluation of current treatment limitations and the potential benefits of early detection.

Main Results:

  • Gastrointestinal involvement is highly prevalent in SSc, ranging from mild symptoms like bloating to severe issues like malabsorption and weight loss.
  • While not typically a direct cause of death, GI manifestations significantly impair quality of life and contribute to comorbidities.
  • Current treatments offer limited benefits in halting disease progression.

Conclusions:

  • Gastrointestinal involvement is a major, often overlooked, complication of systemic sclerosis.
  • Early detection of GI manifestations in SSc is essential for mitigating complications such as malnutrition and improving patient outcomes.
  • Further research into effective treatments for SSc-related GI dysfunction is warranted.