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Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
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Nasal screening is useful in excluding methicillin-resistant Staphylococcus aureus in ventilator-associated pneumonia

Jens Langsjoen1, Christina Brady2, Elisabeth Obenauf3

  • 1Division of Hospital Medicine, University of New Mexico, Albuquerque, NM.

American Journal of Infection Control
|September 3, 2014
PubMed

Insights

Screening for Methicillin-resistant Staphylococcus aureus (MRSA) can guide antibiotic use in intensive care units. Negative MRSA nasal swabs accurately predicted the absence of MRSA ventilator-associated pneumonia in adults.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Clinical Microbiology

Background:

  • Intensive care units (ICUs) face challenges with healthcare-associated infections.
  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in ICUs.
  • Ventilator-associated pneumonia (VAP) is a common ICU-acquired infection.

Purpose of the Study:

  • To evaluate the utility of MRSA screening in guiding antibiotic stewardship.
  • To determine the predictive value of admission MRSA nasal swabs for subsequent MRSA VAP.

Main Methods:

  • A cohort study design was employed.
  • Adult patients admitted to the ICU requiring mechanical ventilation were included.
  • Admission nasal swabs for MRSA screening were analyzed.

Main Results:

  • The negative predictive value of admission MRSA nasal swabs for MRSA VAP was 94%.
  • MRSA screening demonstrated potential utility in infection control decisions.

Conclusions:

  • Admission MRSA nasal screening can be a valuable tool for infection control in the ICU.
  • Negative MRSA screening results can inform decisions about broad-spectrum antibiotic use, potentially reducing unnecessary exposure.
Keywords:
Antibiotic stewardshipCAPMRSAMRSA colonization

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