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Related Experiment Videos

Rectal effluent as a research tool.

Jana M Rocker1, Jack A DiPalma, Lewis K Pannell

  • 1University of South Alabama Mitchell Cancer Institute, Mobile, AL, USA, jrocker@health.southalabama.edu.

Digestive Diseases and Sciences
|September 3, 2014
PubMed
Summary

Gastrointestinal (GI) lavage fluid, collected noninvasively via rectal effluent, offers a rich resource for research. This review explores its applications and methods for collection and analysis.

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Area of Science:

  • Gastroenterology
  • Clinical Research
  • Biomarker Discovery

Background:

  • Localized secretions offer superior molecular insights compared to blood.
  • Lavage techniques efficiently collect cells and soluble factors from body cavities.
  • Gastrointestinal (GI) lavage fluid, particularly rectal effluent, is an abundant, underutilized research resource.

Purpose of the Study:

  • To review the applications of rectal effluent as a research tool.
  • To consolidate information on methods for collecting, stabilizing, and analyzing GI lavage fluid.
  • To address the challenge of locating studies due to varied terminology for rectal effluent.

Main Methods:

  • Review of existing literature on rectal effluent applications in research.
  • Discussion of methods for noninvasive collection of GI lavage fluid (e.g., via toilet receptacle).
  • Exploration of techniques for sample stabilization and analysis.

Main Results:

  • Rectal effluent has been successfully used to study various GI conditions, including diarrheal disease, inflammatory bowel disease, celiac disease, and cancer.
  • Noninvasive collection methods are feasible and yield significant research material.
  • Standardized terminology and comprehensive reviews are lacking, hindering literature discovery.

Conclusions:

  • GI lavage fluid represents a valuable, largely untapped resource for basic and clinical research.
  • Standardized collection and analysis methods are needed to maximize its potential.
  • Further research and reviews are essential to establish rectal effluent as a mainstream research tool.

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