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Area of Science:

  • Pharmacology
  • Hepatology
  • Internal Medicine

Background:

  • Cephalexin is a widely used oral antibiotic with known potential side effects.
  • Cholestatic jaundice is an infrequent but serious adverse reaction associated with cephalexin use.

Purpose of the Study:

  • To report a rare case of cephalexin-induced cholestatic jaundice.
  • To highlight the importance of clinical suspicion for timely diagnosis and management.

Main Methods:

  • A case study of a 57-year-old male patient presenting with symptoms of cholestatic jaundice.
  • Monitoring of liver function tests (LFTs) and clinical presentation.
  • Treatment involved discontinuation of cephalexin and symptomatic management with cholestyramine.

Main Results:

  • The patient exhibited elevated LFTs indicative of cholestatic jaundice after cephalexin administration.
  • Discontinuation of cephalexin resulted in clinical improvement.
  • Complete resolution of abnormal LFTs was observed within four weeks.

Conclusions:

  • Cephalexin can induce cholestatic jaundice, although rare.
  • Early recognition and withdrawal of the causative agent are crucial for recovery.
  • This case underscores the need for high clinical suspicion in diagnosing drug-induced liver injury.