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Updated: Apr 24, 2026

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Published on: May 31, 2021
Chronic spontaneous urticaria is characterized by lower serum advanced glycation end-products
Alicja Grzanka1, Aleksandra Damasiewicz-Bodzek2, Edyta Machura3
1Chair and Clinical Department of Internal Diseases, Dermatology and Allergology, Ulica M. Curie-Skłodowskiej 10, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.
Background:
Chronic spontaneous urticaria (CSU) is associated with activation of acute phase response. On the other hand, it is known that systemic inflammation may lead to increased formation of advanced glycation end-products (AGEs), associated with pathogenesis of various diseases.
Aim:
We aim to test whether chronic inflammation manifested by activated acute phase response may provide a mechanism for increased serum AGEs concentration in CSU.
Methods:
Concentrations of AGEs were measured spectrofluorimetrically in serum of CSU patients and the healthy subjects.
Results:
Serum AGEs and albumin concentrations in CSU patients were significantly lower as compared with the healthy subjects. Serum CRP concentration was significantly higher in patients with CSU than in the controls. Significant positive correlation was observed between AGEs and albumin concentrations in the subjects.
Conclusions:
CSU is not associated with increased circulating AGEs concentrations, despite the enhanced systemic inflammatory response. Paradoxical decrease of serum AGEs concentrations is probably a reflection of lower concentration of "negative acute phase proteins" such as albumin.
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