Peripheral and central glucose sensing in hypoglycemic detection
Casey M Donovan1, Alan G Watts2
1Department of Biological Sciences, The Center for NeuroMetabolic Interactions, USC Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California Donovan@usc.edu.
Abstract:
Hypoglycemia poses a serious threat to the integrity of the brain, owing to its reliance on blood glucose as a fuel. Protecting against hypoglycemia is an extended network of glucose sensors located within the brain and in the periphery that serve to mediate responses restoring euglycemia, i.e., counterregulatory responses. This review examines the various glucose sensory loci involved in hypoglycemic detection, with a particular emphasis on peripheral glucose sensory loci and their contribution to hypoglycemic counterregulation.
More Related Videos
11:10Membrane Potential Dye Imaging of Ventromedial Hypothalamus Neurons From Adult Mice to Study Glucose Sensing
Published on: November 27, 2013
08:32Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
Related Concept Videos
Hypoglycemia and Glucagon
Hypoglycemia
Hyperglycemia
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
