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Related Experiment Video

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Mapping human brain networks with cortico-cortical evoked potentials.

Corey J Keller1, Christopher J Honey2, Pierre Mégevand3

  • 1Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine, and Feinstein Institute for Medical Research, Manhasset, NY, USA Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|September 3, 2014
PubMed
Summary

Cortico-cortical evoked potential (CCEP) mapping offers a novel method to study the human cerebral cortex. This technique directly measures neuronal signals, providing superior spatio-temporal resolution for understanding brain networks.

Keywords:
cortico-cortical evoked potentialeffective connectivityelectrocorticographygraph theorystimulation

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • The human cerebral cortex is a complex network of interconnected neuronal modules.
  • Understanding information flow and causal hierarchical structure within cortical networks is crucial.
  • Invasive electrode monitoring in epilepsy patients offers a unique opportunity to study cortical organization.

Purpose of the Study:

  • To review the potential of cortico-cortical evoked potential (CCEP) mapping for measuring neuronal propagation.
  • To discuss CCEP generation mechanisms and their relation to effective connectivity.
  • To highlight CCEP mapping's insights into non-invasive imaging signals and present a novel perturbation approach.

Main Methods:

  • Utilizing invasive electrode monitoring data from epilepsy patients.
  • Applying cortico-cortical evoked potential (CCEP) mapping to measure neuronal propagation.
  • Introducing a novel method for perturbing and measuring brain network function during cognitive tasks.

Main Results:

  • CCEP mapping provides direct measurement of neuronal propagation across large-scale brain networks.
  • This method offers superior spatio-temporal resolution compared to traditional neuroimaging.
  • CCEP mapping offers insights into the neural basis of non-invasive imaging signals.

Conclusions:

  • Cortico-cortical evoked potential (CCEP) mapping is a powerful tool for probing human cerebral cortex networks.
  • Direct measurement of CCEPs via electrical stimulation advances clinical and basic neuroscience research.
  • This technique enhances our understanding of large-scale brain network function.