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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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Assessing right ventricular function in patients with hypertrophic cardiomyopathy with cardiac MRI: correlation with

Shuai Zhang1, Zhi-Gang Yang1, Jia-Yu Sun1

  • 1Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Plos One
|September 3, 2014
PubMed

Insights

3.0-T MRI effectively assesses right ventricular (RV) function in hypertrophic cardiomyopathy (HCM) patients. RV dysfunction on MRI predicts severe symptomatic HCM, correlating with advanced New York Heart Association (NYHA) classification.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by left ventricular hypertrophy.
  • Right ventricular (RV) involvement is common in HCM and can impact prognosis.
  • Accurate assessment of RV function is crucial for managing HCM patients.

Purpose of the Study:

  • To evaluate the utility of 3.0-Tesla (3.0-T) magnetic resonance imaging (MRI) in assessing RV function in HCM patients.
  • To determine the correlation between RV function parameters measured by MRI and the New York Heart Association (NYHA) functional classification.

Main Methods:

  • Forty-six HCM patients and 23 controls underwent 3.0-T MRI to measure left and right ventricular function and dimensions.
  • Ventricular volumes (end-diastolic [EDV], end-systolic [ESV]), stroke volume (SV), and ejection fraction (EF) were analyzed.
  • Statistical analyses, including independent t tests, ANOVA, and Receiver Operating Characteristic (ROC) analyses, were performed.

Main Results:

  • Significant differences in ventricular volumetric values and masses were observed between HCM patients and controls (p<0.05).
  • RV end-diastolic diameter (RVEDD) correlated with left ventricular end-diastolic diameter (LVEDD) (r=0.53; p<0.001).
  • Patients with NYHA Class IV demonstrated significantly impaired RV and LV systolic and diastolic function compared to Classes I-III (P<0.0167).
  • ROC analyses identified EDV, ESV, and EDD of both ventricles as predictors of severe heart failure (NYHA Class IV) with high sensitivity and specificity.

Conclusions:

  • RV involvement in HCM is comparable to LV global function impairments.
  • 3.0-T MRI is a valuable tool for detecting RV dysfunction in HCM.
  • MRI-detected RV dysfunction and decreased dimensions can predict severe symptomatic HCM.
Abstract

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