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Vascular limb defects and maternal age.

Hanah Z Nasri1, Marie-Noel Westgate, Eric A Macklin

  • 1Medical Genetics Unit, MassGeneral Hospital for Children, Boston, Massachusetts.

Birth Defects Research. Part A, Clinical and Molecular Teratology
|September 3, 2014
PubMed
Summary
This summary is machine-generated.

Vascular disruption limb defects are not linked to older maternal age. However, infants born to mothers 19 years or younger had a higher incidence of these defects compared to those with preaxial polydactyly.

Keywords:
maternal agevascular disruption limb defects

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Area of Science:

  • Medical research
  • Obstetrics
  • Pediatrics

Background:

  • Chorionic villus sampling, a prenatal diagnostic procedure, is linked to an increased risk of vascular disruption limb defects.
  • Previous studies yielded conflicting results regarding the association between maternal age and these defects.

Purpose of the Study:

  • To investigate the relationship between maternal age and the occurrence of vascular disruption limb defects.
  • To compare the incidence of vascular disruption limb defects in infants born to mothers of different age groups.

Main Methods:

  • Infants with vascular disruption defects were identified from the Active Malformations Surveillance Program (1972-1974, 1979-2011).
  • The occurrence rate of vascular limb defects was compared among maternal age groups (≤19, 20-34, ≥35 years) against preaxial polydactyly rates, adjusting for race.
  • Infants with known causes for defects were excluded.

Main Results:

  • 106 infants had vascular disruption defects and 67 had preaxial polydactyly.
  • No increased risk was observed for infants born to mothers aged 35 and older (17% vs. 25%, p = 0.23).
  • Infants with vascular disruption defects were more common among young mothers (≤19 years) (16% vs. 6.0%, adjusted odds ratio = 5.3, p = 0.017).

Conclusions:

  • Maternal age of 35 years or older was not associated with an increased risk of vascular disruption limb defects.
  • Vascular disruption limb defects were more prevalent in infants born to mothers aged 19 years or younger compared to the preaxial polydactyly group.