Related Experiment Video

Updated: Apr 24, 2026

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
09:05

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells

Published on: August 7, 2017

8.6K

Progenitor/stem cells in renal regeneration and mass lesions

Ping L Zhang1, Jason M Hafron

  • 1Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI, USA, ping.zhang@beaumont.edu.

International Urology and Nephrology
|September 4, 2014
PubMed

Insights

Researchers debate if progenitor/stem cells aid kidney repair after injury. Studies show conflicting evidence, with some identifying stem cells and others suggesting differentiated cells gain stem-like properties, impacting renal regeneration understanding.

Area of Science:

  • Nephrology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Adult kidney regeneration capacity is limited after acute kidney injury.
  • Understanding renal repair mechanisms is crucial for developing treatments for kidney diseases.
  • The role of progenitor/stem cells in renal repair is a subject of ongoing scientific debate.

Purpose of the Study:

  • To review recent advancements in the understanding of progenitor/stem cells in kidney regeneration.
  • To discuss the controversial findings regarding stem cell contributions to renal repair.
  • To highlight emerging issues related to progenitor cells in renal mass lesions.

Main Methods:

  • Literature review of studies investigating progenitor/stem cells in kidney injury and repair.
  • Analysis of conflicting data from different research groups using techniques like lineage tracing.
  • Synthesis of current knowledge on stem cell markers and their role in renal tubules and glomeruli.

Main Results:

  • Identification of CD133 stem cells in parietal epithelium and renal tubules, suggesting a role in repair.
  • Lineage-tracing studies showing no direct contribution of progenitor cells to tubular repair.
  • Observation that differentiated tubular cells can acquire progenitor-like characteristics during repair.

Conclusions:

  • The contribution of progenitor/stem cells to renal regeneration remains controversial and requires further investigation.
  • Differentiated cells may play a more significant role in tubular repair than previously thought, potentially by dedifferentiating.
  • Further research is needed to clarify the precise mechanisms of renal repair and the role of progenitor cells in kidney diseases and lesions.

More Related Videos

Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids07:22

Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids

Published on: September 1, 2023

3.5K
Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development09:43

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

15.5K

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
3.7K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
1.6K
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
4.5K
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
5.0K
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.6K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K