Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct information flows for different whole-body actions across LOTC subdivisions.

Communications biology·2025
Same author

Regulatory Considerations for Development of Wound Dressing Devices Used for Chemical and Radiation Injuries.

Disaster medicine and public health preparedness·2024
Same author

Cloud-Connected Patch-Worn Auscultation Device for Chest Sound Monitoring.

bioRxiv : the preprint server for biology·2024
Same author

A handheld plug-and-play microfluidic liquid handling automation platform for immunoassays.

HardwareX·2023
Same author

A large-scale brain network of species-specific dynamic human body perception.

Progress in neurobiology·2022
Same author

Personal NO<sub>2</sub> sensor demonstrates feasibility of in-home exposure measurements for pediatric asthma research and management.

Journal of exposure science & environmental epidemiology·2022
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026
Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026
See all related articles

Related Experiment Video

Updated: Apr 24, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

20.8K

A smartphone controlled handheld microfluidic liquid handling system.

Baichen Li1, Lin Li, Allan Guan

  • 1Nanophotonics and Microfluidics Laboratory, Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA. zhenyu@gwu.edu.

Lab on a Chip
|September 4, 2014
PubMed
Summary
This summary is machine-generated.

This study introduces a smartphone-controlled, handheld microfluidic system for automated liquid handling. The compact device successfully performs complex immunoassays, paving the way for portable diagnostic tools.

More Related Videos

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology
13:59

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

13.0K
A Versatile Kit Based on Digital Microfluidics Droplet Actuation for Science Education
05:46

A Versatile Kit Based on Digital Microfluidics Droplet Actuation for Science Education

Published on: April 26, 2021

4.5K

Related Experiment Videos

Last Updated: Apr 24, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

20.8K
Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology
13:59

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

13.0K
A Versatile Kit Based on Digital Microfluidics Droplet Actuation for Science Education
05:46

A Versatile Kit Based on Digital Microfluidics Droplet Actuation for Science Education

Published on: April 26, 2021

4.5K

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Point-of-Care Diagnostics

Background:

  • Microfluidics and lab-on-a-chip systems offer precise liquid handling but often require bulky external equipment.
  • Existing systems lack portability and automation for complex assays outside laboratory settings.

Purpose of the Study:

  • To develop a handheld, automated microfluidic liquid handling system controlled by a smartphone.
  • To demonstrate the system's capability in performing complex biochemical assays with minimal user intervention.

Main Methods:

  • Integration of elastomeric on-chip valves with a compact pneumatic system for liquid control.
  • Development of a smartphone interface for system operation and automation.
  • Demonstration using a bead-based HIV1 p24 sandwich immunoassay on a multi-layer PDMS chip.

Main Results:

  • A compact (6 × 10.5 × 16.5 cm, 829 g) handheld system was developed.
  • The system autonomously executed all liquid handling steps for an HIV1 immunoassay.
  • The device operated for 8.7 hours on battery power, consuming 2.2 W on average.

Conclusions:

  • The developed system enables automated, complex microfluidic liquid handling in a portable format.
  • This technology has broad applicability for various biochemical and cell-based assays, including FISH, PCR, and nucleic acid sequencing.
  • Integration with biosensors could lead to Tricorder-like handheld in vitro diagnostic (IVD) systems.