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Mapping knowledge translation and innovation processes in Cancer Drug Development: the case of liposomal doxorubicin

David Fajardo-Ortiz, Luis Duran, Laura Moreno

  • 1Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico. meneses@unam.mx.

Journal of Translational Medicine
|September 4, 2014
PubMed

Insights

This study maps knowledge translation and innovation in drug delivery, using network analysis to trace the development of liposomal doxorubicin (Doxil). The findings offer a methodological tool for managing innovation in pharmaceutical research.

Area of Science:

  • Pharmaceutical Sciences
  • Biotechnology
  • Innovation Management

Background:

  • Understanding knowledge translation and innovation processes is crucial for developing new therapeutics.
  • Liposomal doxorubicin (Doxil) serves as a case study for analyzing drug innovation pathways.

Purpose of the Study:

  • To map the structure of knowledge translation and innovation processes in drug delivery.
  • To analyze the historical emergence of nanodrugs like Doxil.
  • To provide a methodological tool for innovation management in pharmaceutical research.

Main Methods:

  • Literature network analysis using Cytoscape.
  • Semantic analysis utilizing GOPubmed, based on MeSH and GO vocabularies.
  • Mapping technological development stages (invention, innovation, imitation) and research phases (preclinical, translational, clinical).

Main Results:

  • Identified distinct clusters corresponding to technological development and knowledge translation stages.
  • Successfully mapped the historical development of Doxil as a nanodrug.
  • Demonstrated the interconnectedness of research phases in nanodrug innovation.

Conclusions:

  • The study provides a robust methodological framework for analyzing and managing innovation in drug delivery.
  • This approach can guide decision-making in pharmaceutical research and development.
  • Mapping innovation pathways enhances understanding of nanomedicine evolution.

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