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Tissue damage control in disease tolerance.

Miguel P Soares1, Raffaella Gozzelino1, Sebastian Weis1

  • 1Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal.

Trends in Immunology
|September 4, 2014
PubMed
Summary
This summary is machine-generated.

Disease tolerance limits disease severity by controlling tissue damage, not by reducing pathogen load. This study explores cellular adaptation mechanisms for tissue damage control and their therapeutic potential.

Keywords:
damage responsedisease toleranceinfectionstress responsetissue damage control

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Area of Science:

  • Host-pathogen interactions
  • Immunology
  • Cellular stress responses

Background:

  • Host defense relies on immune resistance, which targets pathogen load.
  • Disease tolerance offers protection by mitigating disease severity without affecting pathogen levels.

Purpose of the Study:

  • To propose that tissue damage control is a key mechanism of disease tolerance.
  • To explore cellular adaptation strategies for tissue damage control during infection and sterile inflammation.
  • To discuss the therapeutic implications of targeting these mechanisms.

Main Methods:

  • Review and integration of existing literature on cellular stress and damage responses.
  • Analysis of disease tolerance mechanisms in the context of host-pathogen interactions.
  • Exploration of cellular adaptation pathways.

Main Results:

  • Tissue damage control is proposed as a central tenet of disease tolerance.
  • Cellular adaptation mechanisms, integrating stress and damage responses, are crucial for tissue damage control.
  • These mechanisms operate during both infectious and sterile inflammatory conditions.

Conclusions:

  • Disease tolerance functions primarily through tissue damage control.
  • Understanding cellular adaptation in response to damage is critical for disease tolerance.
  • Targeting these pathways holds promise for novel therapeutic strategies against various diseases.