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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

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Sublingual immunotherapy: current concepts for the U.S. practitioner.

Sandra Y Lin1

  • 1Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, MD.

International Forum of Allergy & Rhinology
|September 4, 2014
PubMed
Summary
This summary is machine-generated.

Sublingual immunotherapy (SLIT) effectively reduces allergic rhinitis symptoms and medication needs. This safe treatment offers a convenient alternative to traditional injection immunotherapy for eligible patients.

Keywords:
allergy desensitizationallergy immunotherapyoral immunotherapyspecific immunotherapysublingual immunotherapy

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Area of Science:

  • Allergy and Immunology
  • Pharmacology

Background:

  • Allergic rhinitis affects 20-40% of the U.S. population.
  • Allergen-specific immunotherapy (SIT) is an option for patients unresponsive to medical treatment.
  • Sublingual immunotherapy (SLIT) involves under-the-tongue allergen dosing to build tolerance.

Purpose of the Study:

  • To review the efficacy and safety of sublingual immunotherapy (SLIT) for allergic rhinitis.
  • To assess SLIT as an alternative to pharmacotherapy and injection immunotherapy.

Main Methods:

  • Systematic review of published English language scientific literature.
  • Focus on systematic reviews and randomized controlled trials of SLIT for inhalant allergic rhinitis.

Main Results:

  • SLIT is a safe and effective immune-modulating treatment for allergic rhinitis.
  • SLIT decreases both symptoms and medication requirements.
  • Further research is needed on comparative effectiveness, multi-allergen use, special populations, and optimal dosing.

Conclusions:

  • Sublingual immunotherapy (SLIT) is a safe and effective treatment for allergic rhinitis.
  • SLIT provides a convenient alternative to injection immunotherapy for suitable patients.