Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

270
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
270
Allergic Reactions02:06

Allergic Reactions

26.2K
Overview
26.2K
Hypersensitivities01:30

Hypersensitivities

7.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.2K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

201
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
201
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Antibody Structure01:10

Antibody Structure

51.5K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
51.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dosing of sublingual immunotherapy for allergic rhinitis: evidence-based review with recommendations.

International forum of allergy & rhinology·2015
Same author

Sublingual Immunotherapy: Past, present, paradigm for the future? A review of the literature.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2007
Same author

The use of demineralized bone matrix for mastoid cavity obliteration.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2004
Same author

Bioactive glass ceramic particles as an alternative for mastoid obliteration: results in an animal model.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2002

Related Experiment Video

Updated: Apr 24, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.1K

Anaphylaxis in the allergy practice.

Bryan D Leatherman1

  • 1Coastal Sinus and Allergy Center-Ear, Nose, and Throat Clinic, Coastal Ear, Nose, and Throat Associates, Gulfport, MS.

International Forum of Allergy & Rhinology
|September 4, 2014
PubMed
Summary

Anaphylaxis, a rare but potentially fatal allergic reaction, can occur during allergy testing and immunotherapy. Prompt epinephrine administration and preparedness are crucial for managing these events in otolaryngology offices.

Keywords:
allergyanaphylaxisemergencyimmunotherapyreactionsystemictest

More Related Videos

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.9K

Related Experiment Videos

Last Updated: Apr 24, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.1K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.9K

Area of Science:

  • Allergy and Immunology
  • Otolaryngology
  • Emergency Medicine

Background:

  • Otolaryngologists must consider the risk of anaphylaxis in patients undergoing allergy testing and immunotherapy.
  • Anaphylactic reactions, though rare, can have severe consequences in an office setting.

Purpose of the Study:

  • To review the pathophysiology, incidence, signs, symptoms, and treatment of anaphylaxis.
  • To provide guidance for otolaryngologists managing potential anaphylactic reactions during allergy immunotherapy.

Main Methods:

  • A literature review of recent publications on anaphylaxis was conducted.
  • Key aspects examined include pathophysiology, incidence, clinical manifestations, and treatment strategies.

Main Results:

  • Anaphylaxis is rare in allergy testing/immunotherapy but can be fatal.
  • Rapid onset affects multiple systems; early epinephrine is critical.
  • Risk factors like uncontrolled asthma should be identified for prevention.

Conclusions:

  • Anaphylaxis is infrequent in allergy offices with adherence to proper protocols.
  • Vigilance and preparedness are essential for favorable outcomes in anaphylactic episodes.