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Updated: Apr 24, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
In silico analysis of genomic data for construction of nuclear receptor network
1Division of Cancer Medicine, Department of Systems Biology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Blvd., Unit 950, Houston, TX, 77030, USA.
Abstract:
Availability of genome-wide information in public database provides unprecedented opportunity for developing new strategy to uncover potential interactions of members in large functional family. Here we describe a systematic strategy for constructing and analyzing potential interaction map to uncover novel interaction between nuclear receptors that may play important roles in human disease. This in silico approach can prioritize candidate interactions for further functional validation and assess its clinical relevance.
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