Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retina

The Retina

The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

The Retinoblastoma Gene

The Retinoblastoma Gene

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spatial mapping of human colonic niches reveals rapid, mucus-specific microbiota disruption after bowel cleansing.

Gut microbes·2026

Same author

An Old Story Back: Human Milk Antibodies' Protective Roles Against Allergy Development.

Allergy·2026

Same author

Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation.

Gut microbes·2025

Same author

Intestinal low-abundant bacteria drive MyD88/Trif-dependent CD8<sup>+</sup> T cell exhaustion in chronic myeloid leukemia.

Cell reports·2025

Same author

A Prospective Interventional Study to Evaluate the Effect of Hypoxia on Healthy Volunteers and Patients With Inflammatory Bowel Disease: The Altitude Inflammatory Bowel Disease Study.

The American journal of gastroenterology·2025

Same author

A global survey of taxa-metabolic associations across mouse microbiome communities.

Cell host & microbe·2025

Search research articles

Related Experiment Video

Updated: Apr 24, 2026

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

An ambulance for retinol.

Stephanie C Ganal¹, Andrew J MacPherson²

¹Stephanie C Ganal is in the DKF Maurice Müller Laboratories, University of Bern, Bern, Switzerland.

|September 4, 2014

Summary

This summary is machine-generated.

Serum amyloid A proteins are crucial during inflammation, transporting essential retinol to infected tissues. This process aids in managing infection responses within the body.

Keywords:

acute phase response crystal structure retinol transport serum amyloid A

More Related Videos

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

Published on: December 27, 2024

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Published on: January 28, 2013

Related Experiment Videos

Last Updated: Apr 24, 2026

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

Published on: December 27, 2024

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Published on: January 28, 2013

Area of Science:

Biochemistry
Immunology
Molecular Biology

Background:

Inflammation is a complex biological response to harmful stimuli.
Retinol (Vitamin A) plays a vital role in immune function.
Serum amyloid A (SAA) proteins are acute-phase reactants involved in inflammation.

Purpose of the Study:

To elucidate the role of serum amyloid A proteins in retinol transport during inflammatory conditions.
To investigate the mechanism by which SAA proteins deliver retinol to infected tissues.

Main Methods:

Utilized in vitro assays to study SAA-retinol binding.
Employed cell culture models of inflammation.
Analyzed retinol levels in tissues using mass spectrometry.

Main Results:

Demonstrated direct binding between SAA proteins and retinol.
Observed increased SAA-mediated retinol transport to inflamed cells.
Confirmed the delivery of retinol to infected tissues via SAA.

Conclusions:

SAA proteins actively transport retinol during inflammation.
This transport mechanism is critical for delivering immune-supportive retinol to sites of infection.
SAA-mediated retinol delivery may represent a therapeutic target for inflammatory diseases.